X-Light V3 + DeepSIM Multimodal Imaging Platform
See it in action: a variety of applications!
Multimodal Imaging in One Platform
From Widefield to Spinning Disk Confocal to Super-Resolution: a progressively clearer path to imaging benefits.
Human brain organoids showing CTIP2-positive deep layer cortical neurons (green) and pan-neuronal MAP2 marker (red). Shown left to right are images acquired using: (i) Widefield microscopy, (ii) X-Light V3 Spinning Disk Confocal, and (iii) DeepSIM Super-Resolution. Images were captured with a 20X air objective and are presented as maximum intensity projections from Z-stacks. Sample credits: Prof. Di Angelantonio, CLN2S@Sapienza Università di Roma – IIT.
Click here to read the full application note and explore results at different magnification objectives.
Neuroscience in Depth
Resolving hidden details in depth.
A close-up to visualize
your targeted cellular dynamics
From a high-content approach to single lysosomal vesicle tracking.
On the left, live-cell confocal imaging acquired with the X-Light V3 Spinning Disk system. On the right, super-resolution close-up of the dynamic process of interest, captured using DeepSIM Super-Resolution with a 60X oil immersion objective.High-content imaging with X-Light V3 allows you to broadly identify phenomena of interest and get a general overview across multiple cells. Once the target cell is selected based on your criteria, DeepSIM s enables you to zoom in and follow its dynamics in fine detail. Sample credits: Dr. Lia Asteriti and Dr. Giulia Guarguaglini, Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche @Sapienza Università di Roma.
Click here to see the movie and the lysosome tracking analysis.
Expansion Microscopy
Expansion & multimodal imaging: the perfect combo to raise resolution.
On the left, a whole Thy1‐GFP mouse brain section processed using an expansion microscopy protocol and imaged with the X-Light V3 Spinning Disk Confocal system using a 4X objective, providing a large field of view of the expanded sample. On the right, a specific region of interest analyzed with DeepSIM Super-Resolution, showing neural spines imaged with a 60X oil immersion objective. Sample credits: Dr. Alvaro Crevenna, EMBL-Rome.
Click here to read the full application note.
Dr. Simona RodighieroIEO (Milan)
Already using the X-Light V3 Spinning Disk? Imagine unlocking super-resolution and spinning disk advantages in one powerful, multimodal system. DeepSIM isn’t just an upgrade, it is a leap forward in how you visualize biological detail, accelerating discovery across disciplines. Combine speed, resolution, and depth, all in one workflow.
Don’t just imagine precision, DeepSIM it!
Have Questions? Get in Touch!
